Brain Energy Lab

How does the brain match energy supply and demand, and what happens when it can’t?

Neurons need lots of oxygen and glucose to fuel their electrical activity. To balance energy supply and demand they finely tune their blood supply by signalling to nearby blood vessels to dilate. We’re interested in how this happens during normal brain function, whether this balance is altered at the onset of diseases such as Alzheimer’s disease and how brains respond when this balance is altered so there’s not quite enough oxygen available for normal function. You can find out more about our recent and ongoing research projects here.

Neurons (green) are supplied with energy via a dense and highly-regulated network of blood vessels (red). We use imaging of transgenic mice to track how neurons and blood vessels communicate to balance energy supply and demand.

Who are we?

We’re a research lab based in the School of Psychology and Sussex Neuroscience at the University of Sussex on the south coast of the UK. You can find out more about us here.

The Seven Sisters, East Sussex
The team